Publications

Antisense lncRNA Transcription Mediates DNA Demethylation to Drive Stochastic Protocadherin α Promoter Choice.

Canzio D, Nwakeze CL, Horta A, Rajkumar SM, Coffey EL, Duffy EE, Duffié R, Monahan K, O'Keeffe S, Simon MD, Lomvardas S, Maniatis T.

Cell. 2019 Apr 18;177(3):639-653.e15. doi: 10.1016/j.cell.2019.03.008. Epub 2019 Apr 4.  PMID: 30955885

Writing, Reading, and Translating the Clustered Protocadherin Cell Surface Recognition Code for Neural Circuit Assembly.

Mountoufaris G, Canzio D, Nwakeze CL, Chen WV, Maniatis T.

Annu Rev Cell Dev Biol. 2018 Oct 6;34:471-493. doi: 10.1146/annurev-cellbio-100616-060701.  PMID: 30296392

Solid phase chemistry to covalently and reversibly capture thiolated RNA.

Duffy EE, Canzio D, Maniatis T, Simon MD. 

Nucleic Acids Res. 2018 Aug 21;46(14):6996-7005. doi: 10.1093/nar/gky556 PMID: 29986098

Protocadherin cis-dimer architecture and recognition unit diversity.

Goodman KM, Rubinstein R, Dan H, Bahna F, Mannepalli S, Ahlsén G, Aye Thu C, Sampogna RV, Maniatis T, Honig B, Shapiro L.

Proc Natl Acad Sci U S A. 2017 Nov 14;114(46):E9829-E9837. doi: 10.1073/pnas.1713449114. Epub 2017 Oct 30. PMID: 29087338

Protocadherin cis-dimer architecture and recognition unit diversity.

Goodman KM, Rubinstein R, Dan H, Bahna F, Mannepalli S, Ahlsén G, Aye Thu C, Sampogna RV, Maniatis T, Honig B, Shapiro L.
Proc Natl Acad Sci U S A. 2017 Nov 14;114(46):E9829-E9837. doi: 10.1073/pnas.1713449114. Epub 2017 Oct 30. PMID: 29087338

Distinct roles for motor neuron autophagy early and late in the SOD1G93A mouse model of ALS.

Rudnick ND, Griffey CJ, Guarnieri P, Gerbino V, Wang X, Piersaint JA, Tapia JC, Rich MM, Maniatis T.
Proc Natl Acad Sci U S A. 2017 Sep 26;114(39):E8294-E8303. doi: 10.1073/pnas.1704294114. Epub 2017 Sep 13. PMID: 28904095

Structural origins of clustered protocadherin-mediated neuronal barcoding.

Rubinstein R, Goodman KM, Maniatis T, Shapiro L, Honig B.
Semin Cell Dev Biol. 2017 Sep;69:140-150. doi: 10.1016/j.semcdb.2017.07.023. Epub 2017 Jul 22. Review. PMID: 28743640

Single-cell topological RNA-seq analysis reveals insights into cellular differentiation and development.

Rizvi AH, Camara PG, Kandror EK, Roberts TJ, Schieren I, Maniatis T, Rabadan R.
Nat Biotechnol. 2017 Jun;35(6):551-560. doi: 10.1038/nbt.3854. Epub 2017 May 1. PMID: 28459448

Multicluster Pcdh diversity is required for mouse olfactory neural circuit assembly.

Mountoufaris G, Chen WV, Hirabayashi Y, O'Keeffe S, Chevee M, Nwakeze CL, Polleux F, Maniatis T.
Science. 2017 Apr 28;356(6336):411-414. doi: 10.1126/science.aai8801. PMID: 28450637

Pcdhαc2 is required for axonal tiling and assembly of serotonergic circuitries in mice.

Chen WV, Nwakeze CL, Denny CA, O'Keeffe S, Rieger MA, Mountoufaris G, Kirner A, Dougherty JD, Hen R, Wu Q, Maniatis T.
Science. 2017 Apr 28;356(6336):406-411. doi: 10.1126/science.aal3231. PMID: 28450636

γ-Protocadherin structural diversity and functional implications.

Goodman KM, Rubinstein R, Thu CA, Mannepalli S, Bahna F, Ahlsén G, Rittenhouse C, Maniatis T, Honig B, Shapiro L.
Elife. 2016 Oct 26;5. pii: e20930. doi: 10.7554/eLife.20930. PMID: 27782885

Histone and DNA Modifications as Regulators of Neuronal Development and Function.

Lomvardas S, Maniatis T.
Cold Spring Harb Perspect Biol. 2016 Jul 1;8(7). pii: a024208. doi: 10.1101/cshperspect.a024208. Review. PMID: 27371659

Prevalent presence of periodic actin-spectrin-based membrane skeleton in a broad range of neuronal cell types and animal species.

He J, Zhou R, Wu Z, Carrasco MA, Kurshan PT, Farley JE, Simon DJ, Wang G, Han B, Hao J, Heller E, Freeman MR, Shen K, Maniatis T, Tessier-Lavigne M, Zhuang X.
Proc Natl Acad Sci U S A. 2016 May 24;113(21):6029-34. doi: 10.1073/pnas.1605707113. Epub 2016 May 9. PMID: 27162329

Structural Basis of Diverse Homophilic Recognition by Clustered α- and β-Protocadherins.

Goodman KM, Rubinstein R, Thu CA, Bahna F, Mannepalli S, Ahlsén G, Rittenhouse C, Maniatis T, Honig B, Shapiro L.
Neuron. 2016 May 18;90(4):709-23. doi: 10.1016/j.neuron.2016.04.004. Epub 2016 May 5. PMID: 27161523

Differential Risk Factors for Chronic Obstructive Pulmonary Disease 30-Day Readmissions According to Indication for Readmission.

Glaser JB, Pau D, Maniatis T.
Ann Am Thorac Soc. 2016 Mar;13(3):447. doi: 10.1513/AnnalsATS.201512-813LE. No abstract available. PMID: 26963359

Molecular logic of neuronal self-recognition through protocadherin domain interactions.

Rubinstein R, Thu CA, Goodman KM, Wolcott HN, Bahna F, Mannepalli S, Ahlsen G, Chevee M, Halim A, Clausen H, Maniatis T, Shapiro L, Honig B.
Cell. 2015 Oct 22;163(3):629-42. doi: 10.1016/j.cell.2015.09.026. Epub 2015 Oct 17. PMID: 26478182

CRISPR Inversion of CTCF Sites Alters Genome Topology and Enhancer/Promoter Function.

Guo Y, Xu Q, Canzio D, Shou J, Li J, Gorkin DU, Jung I, Wu H, Zhai Y, Tang Y, Lu Y, Wu Y, Jia Z, Li W, Zhang MQ, Ren B, Krainer AR, Maniatis T, Wu Q.
Cell. 2015 Aug 13;162(4):900-10. doi: 10.1016/j.cell.2015.07.038. PMID: 26276636

hnRNP U protein is required for normal pre-mRNA splicing and postnatal heart development and function.

Ye J, Beetz N, O'Keeffe S, Tapia JC, Macpherson L, Chen WV, Bassel-Duby R, Olson EN, Maniatis T.
Proc Natl Acad Sci U S A. 2015 Jun 9;112(23):E3020-9. doi: 10.1073/pnas.1508461112. Epub 2015 May 26. PMID: 26039991

Astrocytes in neurodegenerative disease.

Phatnani H, Maniatis T.
Cold Spring Harb Perspect Biol. 2015 Apr 15;7(6). pii: a020628. doi: 10.1101/cshperspect.a020628. Review. PMID: 25877220

Exome sequencing in amyotrophic lateral sclerosis identifies risk genes and pathways.

Cirulli ET, Lasseigne BN, Petrovski S, Sapp PC, Dion PA, Leblond CS, Couthouis J, Lu YF, Wang Q, Krueger BJ, Ren Z, Keebler J, Han Y, Levy SE, Boone BE, Wimbish JR, Waite LL, Jones AL, Carulli JP, Day-Williams AG, Staropoli JF, Xin WW, Chesi A, Raphael AR, McKenna-Yasek D, Cady J, Vianney de Jong JM, Kenna KP, Smith BN, Topp S, Miller J, Gkazi A; FALS Sequencing Consortium, Al-Chalabi A, van den Berg LH, Veldink J, Silani V, Ticozzi N, Shaw CE, Baloh RH, Appel S, Simpson E, Lagier-Tourenne C, Pulst SM, Gibson S, Trojanowski JQ, Elman L, McCluskey L, Grossman M, Shneider NA, Chung WK, Ravits JM, Glass JD, Sims KB, Van Deerlin VM, Maniatis T, Hayes SD, Ordureau A, Swarup S, Landers J, Baas F, Allen AS, Bedlack RS, Harper JW, Gitler AD, Rouleau GA, Brown R, Harms MB, Cooper GM, Harris T, Myers RM, Goldstein DB.
Science. 2015 Mar 27;347(6229):1436-41. doi: 10.1126/science.aaa3650. Epub 2015 Feb 19. PMID: 25700176

Resident duty-hour reform: moving beyond "change for change's sake".

Maniatis T.

CMAJ. 2015 Mar 17;187(5):309-10. doi: 10.1503/cmaj.150010.
Epub 2015 Feb 9. No abstract available. PMID: 25667251

Scheduling in the context of resident duty hour reform.

Sun NZ, Maniatis T.

BMC Med Educ. 2014;14 Suppl 1:S18. doi: 10.1186/1472-6920-14-S1-S18.
Epub 2014 Dec 11. Review. PMID: 25561221

An RNA-sequencing transcriptome and splicing database of glia, neurons, and vascular cells of the cerebral cortex.

Zhang Y, Chen K, Sloan SA, Bennett ML, Scholze AR, O'Keeffe S, Phatnani HP, Guarnieri P, Caneda C, Ruderisch N, Deng S, Liddelow SA, Zhang C, Daneman R, Maniatis T, Barres BA, Wu JQ.
J Neurosci. 2014 Sep 3;34(36):11929-47. doi: 10.1523/JNEUROSCI.1860-14.2014. Erratum in: J Neurosci. 2015 Jan 14;35(2):846-6. PMID: 25186741

Single-cell identity generated by combinatorial homophilic interactions between α, β, and γ protocadherins.

Thu CA, Chen WV, Rubinstein R, Chevee M, Wolcott HN, Felsovalyi KO, Tapia JC, Shapiro L, Honig B, Maniatis T.
Cell. 2014 Aug 28;158(5):1045-1059. doi: 10.1016/j.cell.2014.07.012. PMID: 25171406