Research Labs
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The goal of the Al-Hashimi laboratory is to develop new methods for ‘imaging’ the dynamics of nucleic acids at atomic resolution.
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The Axel Lab is primarily concerned with olfaction, or the sense of smell.
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The Califano Lab studies biology from the perspective of the complex networks of gene and protein interactions that define and regulate cell physiology.
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The Fitzpatrick Lab uses cryo-EM to solve the structures of filaments isolated from postmortem brain tissue of patients with a range of neurological disorders.
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The Frank Lab investigates the mechanism of translation on the ribosome by using cryo-electron microscopy and single-particle reconstruction
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The Glasgow lab studies the molecular basis and evolution of protein allostery and designs new functional proteins for applications in therapeutics.
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The Goff laboratory is interested in the replication of the Moloney murine leukemia virus, an oncogenic retrovirus, and Human Immunodeficiency Virus type 1, the cause of AIDS.
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The Greene Lab uses single-molecule optical microscopy to study fundamental interactions between proteins and nucleic acids.
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The Greenwald Lab studies cell-cell interactions, signal transduction, and cell fate specification during C. elegans development, with a focus on LIN-12/Notch.
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The Hendrickson Lab focuses on the structure and function of biological molecules.
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The Hobert Lab studies the gene regulatory control mechanisms that generate the astounding diversity of cell types in the nervous system.
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The Honig Lab focuses on two distinct areas: the molecular basis of cell-cell recognition, and the use of structural information to predict protein function on a genome-wide scale.
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The Kandel Lab studies explicit memory storage (the conscious recall of information about people, places, and objects) in mice and implicit memory storage in the snail Aplysia.
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The Landweber Lab studies novel genetic systems in microbial eukaryotes, bringing a strongly mechanistic approach to understanding genome evolution and diversity.
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The Lomvardas Lab aims to understand the molecular mechanisms of olfactory receptor gene choice.
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The Maniatis lab is involved in understanding fundamental mechanisms of transcription and RNA splicing in the nervous system and how they bear on neuronal connectivity and neurodegenerative diseases.
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The Mann Lab studies how the Hox family of transcription factors bind to the correct DNA sequences and regulate the correct target genes in vivo.
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The Palmer Laboratory in the Department of Biochemistry and Molecular Biophysics uses NMR spectroscopy to study the structures and dynamical properties of proteins and other macromolecules.
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The Shapiro Lab uses structural information obtained from X-ray crystallography to direct biochemical studies of biological problems.
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The Sims Lab develops new tools for single cell and cell type-specific analysis, focusing mainly on transcriptional and translational regulation.
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The Sobolevsky Lab studies structure and function of ion channels using biochemical and biophysical methods, including cryo-EM, X-ray crystallography, electrophysiology and fluorescence measurements.
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The Steckelberg lab focuses on mechanistic, structure-level understanding of host-virus interactions, with a particular interest in interconnections between viral life cycle and nucleic acid biology.
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The Sternberg Lab focuses on mechanisms of nucleic acid targeting by RNA-guided bacterial immune systems and on the development of these systems for genome engineering applications.
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The Tavazoie Lab focuses on how cells adapt to changes in their external environment.
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The Zhang Lab seeks to dissect RNA regulatory networks in the nervous system.
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The Zucker Lab aims to elucidate mechanisms used for signal transduction and information processing in sensory systems.
